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Arg Allele of P53 Gene Codon72 is a Risk Factor for Breast Cancer in Senegalese Women

The proline rich domain of the p53 tumor suppressor protein is necessary for the induction of apoptosis. A common polymorphism, Proline-72-Arginine, alters structural and biological properties of p53. The Arginine allele has been suggested as a risk factor for breast cancer. We investigate by association and segregation studies, the role of Arg72 allele as a risk factor in sporadic and familial breast cancer in Senegalese women. Eighty patients diagnosed with breast cancer followed up at the Curie Institute in Dakar, and eighty-five healthy controls without known cancer, were recruited after informed consent. For each individual, DNA was extracted from whole blood and codon 72 polymorphism genotyped by PCR-RFLP. Our results showed an increased risk for patients carrying Arg/ Arg and Arg/Pro genotypes compared to those carrying Pro/Pro (p<0.03). Similarly, the Arg allele was associated with an increased risk (p<0.03). The codon 72 of p53 might be involved in susceptibility to breast cancer.

Auteur(s) : Dia Y1 , Diop JPD1,2, Ndiaye R1,2,3*, Dem A4 , Diouf D4 , Dieng MM4 , Ba SA1 , Tall FG3 , Ndour EM3 , Gueye PM3 , Ka S4 , Thiam F2 , Thiam A2 , Mbengu
Année de publication : 2017
Revue : Journal of Molecular and Genetic
Type : Article
Mise en ligne par : GUEYE Fatou