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Pulse wave velocity is lower in trained than in untrained sickle cell trait carriers

BACKGROUND: Sickle cell trait (SCT) is a benign condition of sickle cell disease. Nevertheless, previous reports showed that SCT carriers have increased blood viscosity and decreased vascular reactivity compared to non-SCT carrier. The benefit of regular exercise on vascular function has been well documented in the general population but no study focused on the SCT population. PURPOSE: The aim of our study was to compare arterial stiffness and blood viscosity between trained and untrained SCT carriers, as well as a group of untrained non-SCT. METHODS: Arterial stiffness (finger-toe pulse wave velocity) and blood viscosity were evaluated in untrained non-SCT carriers (n = 10), untrained SCT carriers (n = 23) and trained SCT carriers (n = 17) who reported at least 10 hours of physical exercise per week. RESULTS: Untrained SCT carriers had higher pulse wave velocity (p = 0.032) and blood viscosity (p < 0.001) than their trained counterparts. In addition, untrained SCT carriers had higher blood viscosity (p < 0.001) than the untrained non-SCT group. A positive association was noted between blood viscosity and pulse wave velocity in the whole study population. CONCLUSION: Our study suggests that regular exercise may be beneficial for the vascular function of SCT carriers.


Auteur(s) : 1. Valentin Ouedraogo, Philippe Connes, Julien Tripette, Arnaud Jean Florent Tiendrebeogo, Abdou Khadir Sow, Mor Diaw, Moussa Seck, Mountaga Diop, Mag
Pages : 417-424
Année de publication : 2018
Revue : Clinical Hemorheology and Microcirculation
N° de volume : 69
Type : Article
Mise en ligne par : SAMB Abdoulaye