Association between herpes simplex virus type 2 and HIV-1 in a population of married couples from Dakar, Senegal
Numerous studies suggest that herpes simplex virus type 2 (HSV-2) increases the risk of HIV-1 infection but recent
clinical trials of HSV-2 suppressive therapy failed to show an effect. We assessed the putative association between HSV-2 and HIV-1
in a population of HIV-concordant-negative, HIV-1-discordant and HIV-1-concordant-positive married couples from Dakar, Senegal.
In agreement with previous studies, we observed a strong overall association between HSV-2 and HIV-1 (odds ratio 4.61; P, 0.001).
However, this association was mainly determined by a low HSV-2 prevalence in HIV-concordant-negative couples compared with
HIV-1-discordant and HIV-1-concordant-positive couples (23% versus 59% and 66%, respectively; P, 0.001). We observed no
further differences in HSV-2 prevalence between HIV-1-discordant and HIV-1-concordant-positive couples (59% and 66%,
respectively; P ¼ 0.483). Neither the index (59% versus 62%, P ¼ 1.000) nor recipient partners (41% versus 63%, P ¼ 0.131) in
HIV-1-discordant and HIV-1-concordant-positive couples showed significant differences in HSV-2 prevalence. HSV-2 does not
constitute a clear risk factor for HIV-1 infection in this population.
Auteur(s) : Camara M, Seydi M, Dieye TN, Sow PS, Mboup S, Kestens L, Jennes W.
Pages : 810-814.
Année de publication : 2012
Revue : Iint. J. STD AIDS
N° de volume : 23
Type : Article
Mise en ligne par : CAMARA Makhtar