Grave’s disease associated with myasthenia gravis: a case report
Purpose: The unfortunate association between myasthenia gravis and Graves’ disease is not widely
appreciated. It would be consistent with a genetic predisposition for autoimmune disease. The frequency of
this association is variously appreciated in the literature.
Case: We report a case of a 20 years old patient with a two years history of Graves’ disease, who presented
with a myasthenic syndrome leading to an acute respiratory failure. This was found to be reversible
with prostigmine, and the diagnosis of myasthenia gravis (MG) was confirmed by EMG and positive
immunology. There was a positive response to medical treatment.
Discussion: The frequency of this association is variously appreciated in the literature. MG has been
reported to be discovered simultaneously with, or prior to, the diagnosis of Graves’ disease, but is most
commonly subsequent to it. The similarity of symptoms makes diagnosis difficult. Furthermore, an
excess of thyroid hormones worsens MG and the existence of MG imposes certain precautions in the
management of hyperthyroidism.
Conclusion: Research is called for into the surveillance and management of specific manifestations of the
co-occurrence of these conditions.
Auteur(s) : Abdoulaye Pouye*, Diatou Guèye Dia, Souhaibou Ndongo, Atoumane Faye, Nafissatou Diagne Sakho and Fatou Samba Diago Ndiaye
Pages : 4
Année de publication : 25/10
Revue : Internal Medicine Inside
N° de volume : 2
Type : Article
Mise en ligne par : POUYE Abdoulaye