Importance of Electrocardiogram for Detection of Preclinical Abnormalities in Patients with Rheumatoid Arthritis without Cardiovascular Events
Introduction: In patients with rheumatoid arthritis, cardiovascular involvement is common, may have serious
consequences, and can contribute to worsening of patient’s outcome. The realization of systematic electrocardiogram
can help to detect earlier cardiac abnormalities and place in a logical secondary prevention.
Our purpose of this study was to investigate the electrocardiographic abnormalities in a population of Senegalese
patients with rheumatoid arthritis without clinically evident cardiovascular manifestations.
Patients and methods: The study was performed as a cross-sectional study, which included prospectively
73 patients of both sexes aged at least 18 years in the internal medicine department of University Hospital Center
Aristide Le Dantec in Dakar, Senegal, fulfilling the criteria for definite or classical rheumatoid arthritis according
to the criteria of the American Rheumatism Association. It focused on a sample of following clinical examination,
we conducted laboratory tests (CRP, fibrinogen, ESR, Rheumatoid factors: Latex and Waaler Rose, Anti-CCP,
antinuclear factors and antibodies anti-ENA), a standard ECG. Data were analyzed using a descriptive study of the
different variables with the calculation of proportions for categorical variables, and the positional parameters and
dispersion for quantitative variables.
Results: All patients had normal ECG and no cardiac symptoms or dyspnoea on effort. The study included
73 patients (68 females and 5males) with rheumatoid arthritis without obvious cardiac events meet the criteria
of definition of the ACR 1987. The mean age was 44.17 ± 14.43 years with extremes of 18 and 75 years. The
mean duration of RA was 5.93 ± 4.78 years. The concept of family inflammatory arthritis was reported in 35.60%
of cases and almost one in six patients had at least a factor of cardiovascular risk (16.96%). Electrocardiographic
abnormalities found were dominated by left ventricular hypertrophy encountered in 34 patients (46.57%), left atrial
enlargement in 32.90% of cases, 16.44% of patients had left axis deviation. The myocardial hyper excitability was
present in 8 patients (11.19%), including 6 (8.45%) ventricular premature beats found in patients with active RA.
Twenty-six patients had signs consistent with an ischemia and/or myocardial injury is a rate of 35.61%.
Conclusion: The realization of the electrocardiogram in patients with rheumatoid arthritis without clinically
evident cardiovascular manifestations allows highlighting cardiovascular abnormalities related to the natural course
of the disease.
Auteur(s) : Mouhamadounazirou Dodo-Siddo, Simon Antoine Sarr, Mouhamadoubamba Ndiaye, Malick Bodian, Souhaibou Ndongo, Adama Kane, Alassane Mbaye, Maboury Diao, M
Année de publication : 2015
Revue : J arthritis
Type : Article
Mise en ligne par : SARR Simon Antoine