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Cutaneous sarcoidosis presenting with diffuse panniculitis: A case report

Introduction: Cutaneous lesions in sarcoidosis are polymorphic. They can simulate most dermatological conditions. We report a case of cutaneous sarcoidosis presented as diffuse panniculitis. Case Report: A 62-year-old male with no significant past medical history consulted for infiltrated lesion on abdominal skin infiltration lasting for two years. On examination, there were multiple indurated plaques, topped with keratotic papules giving an orange peel view, extending on abdominal genitalia and thighs skin associated with lymph nodes enlargement in different sizes and elastic consistence in axillary and inguinal regions. The histopathological examination of the skin lesion and the lymph nodes revealed typical sarcoidosis granulomas. Thoracic abdominal CT scan was normal. After six months of treatment with methotrexate and prednisone, evolution was remarkable by a rapidly skin lesions des infiltration and disappearance of lymphadenopathy. Conclusion: Cutaneous sarcoidosis as disseminated panniculitis is rarely reported in literature. In our patient, methotrexate combined with prednisone was effective. Other studies have confirmed the efficacy of methotrexate, especially as a steroid sparing treatment. This efficiency would be the result of adenosine production and a decrease in TNF ? secretion in granulomatous lesions.

Auteur(s) : Assane Diop, Diallo Moussa, Maodo Ndiaye, Abbaspour Valiollah,Pauline Dioussé, Boubacar Diatta, Fatimata Ly, Suzanne Oumou Niang, Mame Thierno Dieng,
Année de publication : 2015
Type : Article
Mise en ligne par : DIOP Assane