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Pediatric invasive pneumococcal disease in Senegal

Objectives. – We aimed to describe the clinical, epidemiological, and outcome characteristics of IPD case patients hospitalized at the Albert-RoyerNational Children’s Hospital (French acronym CHNEAR) to evaluate the disease burden of IPDs in a pediatric hospital of Dakar (Senegal).Patients and methods. – All children aged 0–15 years hospitalized at the CHNEAR between January 1st, 2008 and December 31st, 2013 for adocumented IPD were included in the study. Medical history, risk factors, clinical, bacteriological, and outcome data was collected. Data was thenanalyzed using the SPSS software, version 16 (Pearson’s Chi2test: a P-value < 0.05 was considered statistically significant).Results. – A total of 218 IPD patients were hospitalized at the CHNEAR during the study period (hospital prevalence: 0.79%). The mean age was36.1 months. The male to female ratio was 1.27 (122 boys and 96 girls). Infants < 2 years of age represented 61.46% of patients. Prior antibiotictherapy was found in 54% of patients but details were lacking. Infection sites were mostly meningeal (61%) and pleuropulmonary (28.9%). Themain isolated serotypes were 1, 6A, 14, 5, and 23F. Case fatality was 17.4% and it was five times higher for pneumococcal meningitis.Conclusion. – IPDs are very common in children in Senegal. Infants < 2 years of age are particularly affected. The very high case fatality (17%)was significantly associated with meningeal infection sites hence the need for better access to pneumococcal vaccines.

Auteur(s) : I.D. BA, A. BA , P.M. FAYE , A. THIONGANE , M. ATTIYE/KANE , A. SONKO , A. DIOP , I. Deme/Ly ,F.N. Diouf , O. Ndiaye , M.M.M. Leye , M.F. Cissé , M. B
Pages : 463-469
Année de publication : 2015
Revue : Médecine et Maladies infectieuses
N° de volume : 45
Type : Article
Mise en ligne par : BA Idrissa Demba