Tuberculosis among Chronic Hemodialysis Patients: A Senegalese Single Center Experience
Summary: Tuberculosis is a common infectious disease in chronic hemodialysis due to alteration
of the immune system associated with chronic kidney disease. The objectives of this study are to
determine the prevalence of tuberculosis in chronic hemodialysis patients and to identify its diagnostic
and therapeutic difficulties. Methods and patients: This was a descriptive retrospective
study over a period of 20 years (1994-2014). It includes the records of periodic hemodialysis patients
in the Nephrology Department of the Aristide Le Dantec University Teaching Hospital in
Dakar which clinical symptoms and laboratory favor tuberculosis. Results: Of 258 chronic hemodialysis
patients treated in Hospital Aristide Le Dantec hemodialysis center, 29 cases (11.4%) of
tuberculosis disease are diagnosed. The mean age is 43.21 ± 12.48 years, and the sex-ratio is 0.8.
The median time to onset of tuberculosis after initiation of hemodialysis is 22.86 ± 28.86 months.
The diagnosis of tuberculosis is sure only in 17% of cases. Extra-pulmonary sites are found in 79%
of cases. The average duration of treatment is 9.39 ± 1.64 months (6 - 13 months). Various treatment
protocols are adopted. Mortality is 21%, 50% due to disseminated tuberculosis. Conclusion:
The diagnosis of tuberculosis in the chronic hemodialysis patients is often difficult due to the atypical
symptoms, the frequency of extra-pulmonary location and the lack of evidence of sure diagnosis.
Auteur(s) : Mouhamadou Moustapha Cisse1, Rachid El Kabouss1, Yaya Kane2, Sidy Mouhamed Seck3, Ahmed Tall Lemrabott1, Maria Faye1, El Hadji Fary Ka1, Ansoumana Dia
Année de publication : 2015
Revue : Open journal of nephrology
Type : Article
Mise en ligne par : CISSE Mouhamadou Moustapha