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Scleroderma renal crisis in tropical region: two senegalese cases

Scleroderma renal crisis (SRC) is defined as the new onset of accelerated arterial hypertension and /or rapidly progressive oliguric renal failure during the course of systemic sclerosis. It is a rare but life-threatening complication. This formerly serious complication has got a considerable brighter outlook since the introduction of angiotensin converting enzyme inhibitors (ACE) however the mortality is still remaining high. We report two cases of SRC which to our knowledge are the firsts described in Dakar. They were two women aged 45 and 32 years, one of them was previously following for systemic sclerosis. Both of them had malignant hypertension associated with rapidly progressive renal failure, the other was put under corticosteroid therapy four months before SRC occurrence. The histological and laboratory finding showed thrombotic microangiopathy. The height blood pressure returned to normal value after treatment with ACE inhibitors. The final outcome was undesirable with the death of one after two months due to the hemodialysis discontinuation and persistence of renal failure in the other.

Auteur(s) : Mouhamadou Moustapha Cisse1,&, Sidy Mohamed Seck2, Daher Abdoul Karim Oumar1, Khodia Fall1, Ahmed Tall Lemrabott1, Moussa Diallo3, Maria Faye1, Mousta
Année de publication : 2015
Revue : Pan African Medical Journal.
Type : Article
Mise en ligne par : CISSE Mouhamadou Moustapha