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Respective Prevalence of High-Risk HPV Genotypes in Cervical Neoplasia in Senegal

Objectives: In the perspective of prophylactic vaccination against high-risk human papillomavirus (HPV), we analyzed the viral epidemiology of cervical neoplasia in Senegal. Methods: All patients were treated at the Institut Joliot Curie du Cancer in Dakar. HPV genotypes were characterized using a Real-time PCR-based approach and sequencing. Results: Histologically, there were 224 invasive carcinomas, 17 high-grade intraepithelial neoplasia (CIN), and 5 undetermined histologies. Molecular analysis was conclusive in 241 cases. HPV DNA was found in 207/241 (85.9%) cases while 34/241 (14.1%) remained HPV negative. There was one single genotype in 127/207 (61.4%) cases and several in 80/207 (38.6%) corresponding to 308 genotypes identified. Viral genotyping found HPV16 in 175 (56.8%) cases, HPV18 in 45 (14.6%), HPV45 in 40 (13.0%), HPV58 in 35 (11.4%), HPV33 in 6 (2.0%), HPV35 in 3 (1.0%), HPV31 in 2 (0.6%), HPV39 and HPV56 in one (0.3% each). Conclusion: Our analysis showed that 98.4% of the HPV-positive cases were associated with viral genotypes covered by the 9-valent HPV vaccine. However, 14.1% cases remained HPV negative. Therefore, prophylactic vaccination using 9-valent vaccine should dramatically reduce the incidence of HPV-associated neoplasia but the detection and treatment of CIN remains necessary for the optimal prevention of cervical cancer. This article is protected by copyright. All rights reserved.

Auteur(s) : Diop-Ndiaye H, Sastre-Garau X, Drame A, Dembele B, Ba NN, Diop-Diongue O, Mbow M, Diakhaby MEB, Woto-Gaye G, Kane CT, Diop M
Année de publication : 2021
Revue : J Med Virol
Type : Article
Mise en ligne par : DIOP Halimatou