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Evolution of acute gastroenteritis in children under five years at CHNEAR after the introduction of the rotavirus vaccine into the EPI

Background: Acute gastroenteritis (AGE) is a leading cause of morbidity and mortality among chil- dren <5 years in developing countries, rotavirus being most common etiology. In November 2014, monovalent rotavirus vaccine was introduced in Senegal EPI. We determined the effectiveness of rotavirus vaccine on AGE in children <60 months of age. Patients and Methods: This is a monocentric and retrospective study of AGE and rotavirus AGE. Analysis was done with two periods, before (2011- 2014) and after (2015-2017) rotavirus vaccine introduction in Senegal EPI. There were 3 age groups: (0-11, 12-23 and 24-59 months). Results: A total of 673 patients <60 months were hospitalized for AGE, 30% (203/673) due to rotavirus. In pre-vaccine years, median proportion of rotavirus-positive hospitalizations was 41,5%; this proportion declined by 76% to 10% rotavirus-positive in 2015-2016 (p<0.001) and by 59% to 17% in 2016-2017(p<0.001). From the logbook data, among all children <60 months, a median of 11% of all hospitalizations in the pre-vaccine period were due to AGE, with 2015-2016 seeing an 16% decline (p<0.001), to 9% of all hospitalizations, and 2016-2017 seeing a 39% decline (p<0.001), to 7% of all hospitalizations. Declines in both rotavirus-associated and all- cause AGE hospitalizations were most marked among infants, with a suggestion of herd effect among older children in the surveillance data. Conclusion: Our study suggests that the rotavirus vaccine has a positive impact on AGE in children under 5 in CHNEAR. Its use must be perpetuated. Keywords : gastroenteritis, rotavirus, rotavirus vaccine, Senegal

Auteur(s) : Thiongane A , Diop A , Diéye B , Sonko A , Faye PM , Ndiaye O .
Année de publication : 2020
Type : Article
Mise en ligne par : DIEYE Baïdy