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Synthesis, Characterization and Antimicrobial Activities of 1,4-Disubstituted 1,2,3-Triazole Compounds

Abstract: Background: 1,2,3-triazoles are five-membered heterocyclic scaffold; their broad-spectrum biological activities are known. Researchers around the world are increasingly being interested in this emerging area, owing to its immense pharmacological scope. Objective: This work summarizes the synthesis of 1,2,3-triazoles and the significance of this pattern as a lead structure for new drug molecules discovery. Methods: 1,2,3-triazoles can be obtained on a multigram scale through “click chemistry” under ambient conditions. Results: Sixteen compounds were synthesized and evaluated on five microbial strains E. coli, E. fae- calis, P. aeruginosa, S. aureus and C. albicans. NMR, MS and IR were used to characterize all com- pounds. They were evaluated with their Minimum Inhibitory Concentrations (MICs) and interesting re- sults were obtained with compounds 12a, 12b, 3, 2a and 2c, with MIC 0.14 µM (P. aeruginosa), 1.08 µM (E. coli), 1.20 µM (E. faecalis and C. albicans), 3.5 µM (E. faecalis) and 4.24 µM (C. albicans), respectively. P. aeruginosa and C. albicans were the most sensitive among all the strains. Conclusion: The synthesized compounds were found as potential antimicrobial agents against Gram (+), Gram (-) strains and fungi


Auteur(s) : Seck Insa, Fall Alioune, Ba Lalla Aicha, Ndoye Samba Fama, Ka Seydou, Diop Abdoulaye, Ciss Ismaïla, Ba Abda, Diop Amadou, Boye Cheikh Sadibou, Gomez G
Pages : 2289-2299.
Année de publication : 2020
Revue : Current Topics in Medicinal Chemistry
N° de volume : 20
Type : Article
Mise en ligne par : SECK Matar