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Cytotoxicity of Roots Methanolic Extractof Maytenus senegalensis.

The aim of this study was to evaluate toxicity of a methanolic root fraction of Maytenus senegalensis, a medicinal plant commonly used in senegalese pharmacopoeia. Toxicological tests were conducted by In vitro assay. Thus, cell viability was performed by MTT, Neutral Red and LDH activity assays on Caco-2 and HepG2 cell lines and IC50 were determined. Apoptotic activity was evaluated by electrophoretic migration of the DNA extract to determine a potential fragmentation. Results showed that the extract was cytotoxic ones whatever the cell type used, at IC50 < 40 ?g/mL for MTT and LDH. With Neutral Red, IC50 was between 60-80 ?g/mL DNA fragmentation has also been observed, indicating the involvement of apoptosis in the cell death mechanism. The date will be supplemented by an in vivo evaluation for a better appreciation of the safety of use of M. senegalensis.


Auteur(s) : Fatoumata Bah, Pascale Marie Aimée Dozolme, Mathilde Cabral, Aminata Touré, Absa Lam, Théophile Amondo Mobio, Edmond Ekoue Creppy, Matar Seck, Mamadou
Pages : 011-016
Année de publication : 2020
Revue : Advanced Journal of Toxicology: Current Research,
N° de volume : 4(1)
Type : Article
Mise en ligne par : SECK Matar