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Prealbumin variation in neonatal bacterial infections.

As a malnutrition biomarker, prealbumin or transthyretin (TTR), can detect and reflect various clinical circumstances. In newborns, real malnutrition is rare, and the nutritional situation is relatively constant in the absence of pathologies. However, the management of neonatal bacterial infections remains a major problem due to the non-specificity of clinical signs and diagnostic laboratory markers. This study was conducted in this context to study the variation of prealbumin in neonatal infections. This is a prospective cross-sectional study carried out at the department of pediatric of the Diamniadio children's hospital in 2016. This includes subjects aged between 0 and 28 days admitted for neonatal infection according to clinical and anamnestic criteria. Prealbumin assay was carried out using the immuno-turbidimetry technique with the A15 automate of Biosystems®. In 50 newborns, bacterial neonatal infection was confirmed in 24% of the population. Prealbumin concentration of newborns with isolated germs (179.08±108.87 mg / L) is lower compared to the group where no germ was isolated (199.41±108.87 mg / L) but without significant difference. However, Gram-negative infection was responsible for a greater decrease in prealbumin. It is therefore important to include the dosage of prealbumin in the monitoring of neonatal bacterial infections to prevent complications.


Auteur(s) : Coly NF, Thiam S, Samba A, Bass I, Ndiaye A, IY Soumah, F Diedhiou, Cissé F, Boye O, Djité M, Doupa D, Diagne Gueye NDR, Gueye PM and Agne FD.
Pages : 04-07
Année de publication : 2020
Revue : International Journal of Advanced Biochemistry Research
N° de volume : 4(2)
Type : Article
Mise en ligne par : CISSE Fatou