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Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine initiative: clinical indicators

Abstract Background: Adverse cardiovascular events are a leading cause of perioperative morbidity and mortality. The definitions of perioperative cardiovascular adverse events are heterogeneous. As part of the international Standardized Endpoints in Perioperative Medicine initiative, this study aimed to find consensus amongst clinical trialists on a set of standardised and valid cardiovascular outcomes for use in future perioperative clinical trials. Methods: We identified currently used perioperative cardiovascular outcomes by a systematic review of the anaesthesia and perioperative medicine literature (PubMed/Ovid, Embase, and Cochrane Library). We performed a three-stage Delphi consensus-gaining process that involved 55 clinician researchers worldwide. Cardiovascular outcomes were first shortlisted and the most suitable definitions determined. These cardiovascular outcomes were then assessed for validity, reliability, feasibility, and clarity. Results: We identified 18 cardiovascular outcomes. Participation in the three Delphi rounds was 100% (n¼19), 71% (n¼55), and 89% (n¼17), respectively. A final list of nine cardiovascular outcomes was elicited from the consensus: myocardial


Auteur(s) : Guy Haller, Sohail Bampoe , Tim Cook , Lee A. Fleisher, Michael P. W. Grocott , Mark Neuman , David Story , Paul S. Myles on behalf of the StEP-COMPA
Pages : 228-237
Année de publication : 2019
Revue : British Journal of Anaesthesia,
N° de volume : 123 (2)
Type : Article
Mise en ligne par : DIOUF Elisabeth