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Antibiotic susceptibility profile of Streptococcus pneumoniae isolated from acute respiratory infection in Dakar: a cross sectional study

Streptococcus pneumoniae is a pathogen causing pneumonia, meningitis, otitis and bacteraemia. Nowadays, S. pneumoniae is developing antibacterial resistance, particularly for those with reduced susceptibility to penicillin. The objective of this study was to assess the susceptibility profile of S. pneumoniae strains isolated from acute respiratory infections (ARIs) in children younger than 5 years of age in Dakar, Senegal. S. pneumoniae strains were isolated from broncho-alveolar lavages (BALs), nasopharyngeal swabs, and middle ear secretion from children in the Paediatric Department of Abass Ndao University Teaching Hospital and Paediatric Department of Roi Baudouin Hospital in Dakar, Senegal. The strains were cultivated on Columbia agar supplemented with 5% of horse blood and gentamicin (6 mg/L). Antibiotic susceptibility testing was performed using E-test method. A total of 34 strains of S. pneumoniae were isolated and identified in this study, among them 7 strains (20.58%) showed penicillin-resistance. Antibiotics such as amoxicillin/clavulanic acid (MIC90=0.036 ?g/mL), cefuroxim (MIC90=0.38 ?g/mL), cefixim (MIC90=1.5 ?g/mL), as well as macrolides (azithromycin MIC90=1.5 ?g/mL, clarithromycin MIC90=0.125 ?g/mL) and fluoroquinolone (levofloxacin MIC90=1 ?g/mL, ofloxacin MIC90=2 ?g/mL) were mostly active. However, all S. pneumoniae strains were resistant to sulfamethoxazole/trimethoprim (MIC90: 32 ?g/mL). Except of S. pneumoniae strains penicillin-resistance or reduced susceptibility, most strains were susceptible to ?-lactams antibiotics commonly used in ARI treatment. Continuous surveillance of antimicrobial resistance patterns of pneumococcus strains is still crucial for effective control of ARIs in children.

Auteur(s) : Abdoulaye Diop, Makhtar Camara, Abdoulaye Seck, Assane Dieng, Amadou Diop, Amary Fall, Cherif Ibrahima. Khalil Diop, Djibril Boiro, Jean Baptisse Niok
Pages : 7862
Année de publication : 2018
Revue : Microbiologia Medica
N° de volume : 33
Type : Article
Mise en ligne par : CAMARA Makhtar