Tramadol Encapsulation in Aqueous Phase of Water/Oil Pickering Emulsion Stabilized by Magnesium Oxide Particles]
Pickering emulsions are systems without surfactants, stabilized by solid particles. These emulsions are experiencing a renewed interest, on the one hand, because it is preferable to limit the use of synthetic surfactants for toxicological and environmental reasons and, on the other hand, the need to make new formulations in order to control the drug release patterns by encapsulation or controlled release. Thus, we were interested in the formulation and evaluation of W / O Pickering emulsions stabilized by particles of magnesium oxide with tramadol hydrochloride in the internal phase. The Bancroft rule served as a model for the formulation. The emulsification was carried out by progressively adding an aqueous phase dispersed in an oil-dispersing phase using a turbo rotor stator mixer. The stability of these emulsions was studied using several parameters (droplet size, pH, viscosity, conductivity...) and the qualitative and quantitative analysis of the active ingredient by UV-visible spectrophotometry. The results obtained showed that the dye test and the conductivity measurement confirmed the W / O nature of these emulsions. Some parameters such as droplet size, pH and viscosity were strongly influenced by the amounts of Magnesium oxide particles and the active ingredient. The qualitative and quantitative analysis of the active ingredient confirmed the presence of tramadol in the internal aqueous phase. Thus, we have succeeded in developing a stable W / O Pickering emulsion with magnesium oxide particles. In addition, we were able to encapsulate tramadol in the dispersed aqueous phase.
Auteur(s) : SY, P.M., DIENG, S.M., DIOUF, L.A.D., DJIBOUNE, A.R., SOUMBOUNDOU, M., NDONG, B., DIOP, O., BATHILY, E.H.A.L., GORA MBAYE, M.D., MBODJ, M., DIARRA, M.
Pages : 37-43
Année de publication : 2018
Revue : International Journal of Biochemistry and Biophysics,
N° de volume : 6(2)]
Type : Article
Mise en ligne par : MBAYE Gora