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Hydroxyapatite/ eudragit® matrix for continuous and controlled release of ibuprofen

Hydroxyapatite ceramic biomaterial, whose mineral composition is identicatr to that of bones and teeth is the most used osteoconductive rnaterial for the release of, active principles. In vitro studies have shown its usefulness for controlled release of various active agents (Drug Delivery System) such as antibiotics. Because of its properties, we set a goal to rnake the hydroxyapatite-based matrices mixed antibiotics able to lead to inhibition of a bacterial culture in agar medium. Materials and methods The study of sensitivity was carried out on a strain of Escherichia coli ATCC Z5gZ2. The antibiotic used is a beta-lactam, cefuroxime. Inhibition diameters on MH medium were measured after 24 hours of incubation with the hydroxyapatite disc base loaded with different concentrations of the antibiotic (0.75 to 4.5 mg). Results The results showed very satisfactory diameters of inhibition greater or equal to the control disc loaded with 300 mg of cefuroxime. These inhibition diameters varied according to the initial load of antibiotic' Conclusion The use of hydroxyapatite-based ceramic can be a true alternative to blotter paper discs for the in vitro determination of the sensitivity of bacteria to antibiotics. Moreover, the load antibiotics is small compared to the blotter paper disk impregnated with


Auteur(s) : SY P M, MBAYE G, DIOUF L A D, SOUMBOUNDOU M, DJIBOUNE A R, NDIAYE I M E, NDONG B, NDIAYE A, DIEDHIOU A, DIOP O, BATHILY El H A L, MBODJ M, DIARRA M
Pages : 42-53
Année de publication : 2015
Revue : International Journal of Innovative Science, Engineering & Technology, 2(12)
N° de volume : 2
Type : Article
Mise en ligne par : MBAYE Gora