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Synthesis and Fluorescence Study of a Series of 4-Hydroxycoumarin O-Acylation Drivatives

Some coumarin derivatives were synthesized starting from 4-hydroxycoumarin and benzoyl chlorides. The structures of the obtained compounds were confirmed by mass and NMR spectra. Additionally, their crystal structures were determined by X-ray diffractometry, excepting the compound C1. Absorption and fluorescence spectra of these derivatives have been investigated in acetonitrile medium. The effects of various electron donating substituents R on fluorescence emission were examined. As a result, compound C5 with an electron-donating substituent dimethyl amino (R = Me2N) exhibited the strongest fluorescence.


Auteur(s) : Abdoulaye Djandé, Lamine Cissé, Jules Yoda, Léopold Kaboré and Fabrice Duvernay
Pages : 116-130
Année de publication : 2019
Revue : World Journal of Pharmacy and Pharmaceutical Sciences
N° de volume : 8
Type : Article
Mise en ligne par : CISSE Lamine