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Prevalence and factors associated with positive cryptococcal antigenemia among hiv infected adult hospitalized in Senegal

Background: Cryptoccocal meningitis is a major cause of death for HIV patients in subsaharan Africa. Screening of cryptococcal antigenemia in patients at risk allows early identification of asymptomatic or paucisymptomatic cases. This study aims to determine the prevalence of cryptococcal antigenemia and associated factors in our context. Patients and method: We conducted a cross-sectional study reporting epidemiological, clinical and biological aspects of hospitalized patients during the study period. The serum antigen was measured by latex agglutination. Results: Fifty cases of positive cryptococcal antigenemia were confirmed for 541 HIV infected patients tested, giving a prevalence of 9.2%. Factors significantly associated to a positive cryptococcal antigenemia (p<0,05) were: having a history of cryptococcal cerebromeningitis and presenting at admission headache, altered consciousness or meningeal signs. Conclusion: The prevalence of cryptoccocal antigenemia was high and associated with neuromeningeal signs


Auteur(s) : MANGA NM ,CISSE-DIALLO VMP, DIA-BADIANE N M, DIOP-NYAFOUNA SA, NGOMA YENGO DE , NDOUR CT , DIENG Y, SEYDI M, GIRARD P M , SOW PS
Année de publication : 2016
Revue : Revue tunisienne d'infectiologie
Type : Article
Mise en ligne par : CISSE Viviane Marie Pierre