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HLADH-catalyzed synthesis of ?-amino acids, assisted by continuous electrochemical regeneration of NAD+ in a filter press microreactor

This work focuses on the use of electrochemical microreactors, applied to the direct electroregeneration of nicotinamide dinucleotide (NAD+) used in-situ for the enzymatically-assisted oxidation of the ?-alanine. Mechanistic and chemical/electrochemical reactor approaches were investigated, to achieve satisfactory conversions ( > 80%) of the substrate in reasonable (1–2 days) reaction times; no fouling observed of the gold anode. An original method was proposed to limit the complexation effect of the produced ?-alanine to the enzyme. Simulations of the overall system were achieved and an estimation of the required kinetic and Michaelis constants was proposed.

Auteur(s) : R. A. Rodríguez-Hinestrozaa , C. Lópeza , J. López-Santína, C., Kane, , M. Dolors Benaigesa , T. Tzedakis
Pages : 196-207
Année de publication : 2017
Revue : Chem. Eng. Science
N° de volume : 158
Type : Article
Mise en ligne par : KANE Cheikhou