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Inflammatory cytokine and humoral responses to Plasmodium falciparum glycosylphosphatidylinositols correlates with malaria immunity and pathogenesis

Pro-in?ammatory cytokines induced by glycosylphosphatidylinositols (GPIs) ofPlasmodium falciparum contribute to malaria pathogenesis and hence, thenaturally acquired anti-GPI antibody thought to provide protection against severemalaria (SM) by neutralizing the stimulatory activity of GPIs. In previous studies,the anti-GPI antibody levels increased with age in parallel with the development ofacquired immunity, and high levels of anti-GPI antibodies were associated withmild malaria (MM) cases. In the present study, the relationship between the levelsof pro-in?am matory cytokines and anti-GPI IgG antibody responses, parasitemia,and the clinical outcomes were evaluated in SM and mild malaria (MM) patients.Sera from a total of 110 SM and 72 MM cases after exclu ding of ineligible patientswere analyzed for the levels of anti-GPI antibodies, IgG subclasses, and cytokineresponses by ELISA. While the total anti-GPI antibody levels were similar in overallSM and MM groups, they were signi?cantly higher in surviving SM patients than infatal SM cases. In the case of cytokines, the TNF-a and IL-6 levels were signi?cantlyhigher in SM compared to MM, whereas the IL-10 levels were similar in bothgroups. The data presented here demonstrate that high levels of the circulatory pro-in?ammatory, TNF-a, and IL-6, are indicators of malaria severity, whereas anti-in?ammatory cytoki ne IL-10 level does not differentiate SM and MM cases.Further, among SM patients, relatively low levels of anti-GPI antibodies areindicators of fatal outcomes compared to survivors, suggesting that anti-GPIantibodies provide some level of protection against SM fatality.


Auteur(s) : MBENGUE B., NIANG B., SYLLA NIANG M., VALERA M.L., FALL B., FALL M.M., NDIAYE R.D., DIATTA B.,CHANNE GOWDA D., DIEYE A. PERRAULT R.
Pages : 24-34
Année de publication : 2015
Revue : Immunity, inflammation and disease
N° de volume : 4
Type : Article
Mise en ligne par : SYLLA Maguette Dème