Hydroxyapatite/eudragit® matrix for continuous and controlled release of ibuprofen.
HYDROXYAPATITE/EUDRAGIT® MATRIX FOR CONTINUOUS AND CONTROLLED RELEASE OF IBUPROFEN
We were interested in developing a hydroxyapatite/Eudragit matrix for continuous and controlled release of ibuprofen. The choice of hydroxyapatite and Eudragit (RS 100 and RSPO) as main excipients is justified by the fact that the latter are used to modify the release of active ingredients. In addition, the hydroxyapatite has a mineral whose composition close to that of bone and teeth, gives it the ability to be used as bone restorative material.
Materials and method
We have developed hydroxyapatite/Eudragit matrix with hydroxyapatite annealed at 800°C and not annealed. As plasticizer we used butylphthalate, the active ingredient being ibuprofen which is a nonsteroidal anti-inflammatory used in the treatment of pain and fever. The study of the release of ibuprofen was performed in phosphate buffer medium (pH = 6.8) at room temperature with a UV-visible spectrophotometer ( model 1371 ) at 264 nm and lasted 28 days. For each batch, the study was conducted on three units of known mass.
Quantities released depend on the form of hydroxyapatite used (annealed or unannealed ) but also on the initial load of ibuprofen. The release profiles follow first order kinetics, modeled by the following equation : Qt = Q28 A1 + e- (t / k). This setting allows not only to predict the precise amounts of ibuprofen to release at the sites of action based on need, but also to control the release of the latter.
These results show that hydroxyapatite powder is suitable for the development of a hydroxyapatite/Eudragit matrix for the controlled and sustained release of ibuprofen. Such a system would allowed not only bone or dental restoration but also as well as an adapted and controlled formulation in terms of dose of active principle provided to the patient.
Auteur(s) : SY P M, MBAYE G, DIOUF L A D, SOUMBOUNDOU M, DJIBOUNE A R, NDIAYE I M E, NDONG B, NDIAYE A, DIEDHIOU A, DIOP O, BATHILY El H A L, MBODJ M, DIARRA M
Année de publication : 2015
Revue : International Journal of Innovative Science, Engineering & Technology, Vol. 2 Issue 12, December 2015, p:42-53.
Type : Article
Mise en ligne par : DIARRA Mounibé