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Development and validation of a simple and economical spectrofluorimetric method for estimation of ciprofloxacin in pharmaceutical dosage forms

A new simple, precise, accurate and “green” spectrofluorimetric method for the determination of ciprofloxacin both as a bulk drug and in pharmaceutical formulations was developed and validated using water as solvent. At a predetermined excitation wavelength (280 nm) and emission wavelength (450 nm), it was proved linear in the concentration range of 20250 ng/mL, exhibited good correlation coefficient (R2= 0.9993) and excellent mean recovery (98.40-102.26%). The results of the recoveries studies showed that the method was not affected by the presence of common excipients. The method was applied for the analysis of the drug in the pure, tablet and injectable forms. The method was validated for various parameters according to ICH guidelines. LOD and LOQ for ciprofloxacin were found to be 4.53 ng/mL and 5.67 ng/mL respectively. The method has been successfully applied for the analysis of marketed formulations available in Senegal.


Auteur(s) : SARR SO, NDIAYE SM, FALL D, DIEDHIOU A, DIOP A, NDIAYE B, DIOP YM
Pages : 72-77
Année de publication : 2013
Revue : International Journal of Analytical and Bioanalytical Chemistry
N° de volume : 3
Type : Article
Mise en ligne par : DIOP Amadou