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Serum lipids and oxidized low density lipoprotein levels in sickle cell disease: Assessement and pathobiological significiance.

One hundred and eighteen (118) subjects aged 15 to 36 years divided into control subjects (AA n = 42), heterozygous sickle cell patients (AS n = 33) and homozygous sickle cell patients (SS n = 43) were investigated for a lipid profile including the measurement of oxidized low density lipoprotein (LDL) to assess the risk of early atherosclerosis in sickle cell disease. The results show that total, high density lipoprotein (HDL) and LDL plasma cholesterol levels are significantly lower in the sickle cell patients than in control group (p < 0.05). In contrast, the triglyceride levels, the ratio of triglycerides to HDLcholesterol and the oxidized LDL fraction are higher in patients (p < 0.05). These lipid abnormalities could represent a cardiovascular risk for sickle cell disease patients.


Auteur(s) : Diatta Alassane, Cissé Fatou, Gueye Tall Fatou, Diallo Fatou, Touré Fall Awa Oumar, Sarr Gaston Ndéné, Lopez Sall Philomène, Sall Niama Diop and Touré
Pages : 39-42
Année de publication : 2014
Revue : African Journal Of Biochemistry Research
N° de volume : 8
Type : Article
Mise en ligne par : CISSE Fatou