Kaposi’s Disease (KS) in a Senegalese Child Living with HIV
Kaposi’s Disease or Kaposi’s Sarcoma (SK ) is a multifocal malignant proliferation
induced by viral growth factors, including interleukin 6 of human
herpes virus type 8 (HHV8). We describe four forms of this disease who poses
a real public health problem in East and Central Africa. The purpose of our
observation was to report a rare condition in a Senegalese HIV-positive child.
It was an 11-year-old girl from a region in central Senegal. She was an orphan
of both parents, tested and monitored since the age of 5 for HIV infection 1.
She was on the 1st line protocol. Due to a lack of support and good observance,
she was referred to us at the age of 11 for follow-up in our structure in
the suburbs of Dakar. The initial follow-up assessment showed a very low
CD4 count and a very high viral load. Before the lack of clinical and immune-
virological response, a genotypic resistance test was performed and
showed immunological and virological failure. The initial development was
marked by the appearance of lesions which were highly suggestive of Kaposi’s
disease. She was on 2nd line treatment. The histopathological aspect of
cutaneous biopsy was very suggestive of Kaposi’s disease. The subsequent
course after ART and bleomycin treatment was clinically marked by regression
of skin lesions. Virologically, it was marked by a fall in the viral load.
Immunologically there was a gradual recovery of CD4 levels which came back
to normal. Our observation demonstrates that absence of effective antiretroviral
therapy for HIV increases the risk to develop Kaposi’s sarcoma.
Auteur(s) : F. Ly, B. Niang, Y. Keita, C. Dial, A. Sow, A. Sakho Kane, B. S. Ndiaye, A. Sylla, B. Camara, A. Ly Ba, O. Ndiaye
Année de publication : 2020
Revue : Open Journal of Pediatrics
Type : Article
Mise en ligne par : NIANG Babacar