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Activité anti-inflammatoire de l'extrait aqueux des feuilles de Elaeis guineensis Jacq. (ARECACEAE) sur l'oedème aigu de la patte de rat induit par la carraghènine

Elaeis guineensis is often used in african traditional medicine in the treatment of many diseases. This work aimed to make a phytochemical study and determine the anti-inflammatory activity of aqueous extract of leaves of this plant. Carrageenan-induced rat paw edema model was used for this study. We tested the aqueous extract of the leaves at doses of 300 and 500 mg/kg. Oral administration of aqueous extract of leaves at dose of 300 mg/kg, prevents significantly (p<0.05) carrageenan-induced rat paw edema. Increasing percentage of inflammatory paw edema is 25,94±6,17 ; 34,81±10,55 et 51,65±16,93 respectively at T1h, T3h et T6h after carrageenan injection. It is 19,73±5,09 ; 24,32±4,20 et 32,15±4,08 at the dose of 500 mg/kg respectively at T1h, T3h et T6h after carrageenan injection. These results show that Elaeis guineensis leaves have anti-inflammatory activity that justifies its use in african traditional medicine to prevent or treat inflammation.


Auteur(s) : Madièye SENE1* , Mamadou NDIAYE1 , Firmin Sylva BARBOZA1 , Mbaye SENE2 , William DIATTA3 , Abdou SARR3 , Awa NDIAYE-SY1 , Amadou Moctar DIEYE1 et Guat
Pages : 2568-2574
Année de publication : 2016
Revue : Int. J. Biol. Chem. Sci.
N° de volume : 10(6)
Type : Article
Mise en ligne par : NDIAYE Mamadou