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Extra nodal natural killer/T-cell lymphoma, nasal type in Senegal

Introduction The distribution of extranodal NK/T-cell lymphoma (ENKTCL) is highly inhomogeneous throughout the world. In Sub-Saharan Africa, despite the precocity of Epstein-Barr virus (EBV) infection and its endemicity, ENKTCLremains exceptionally reported. The purpose of this study was to report the epidemiological, clinical, paraclinical, and evolutionary characteristics of ENKTCL at the Aristide LeDantec University Hospital in Dakar, Senegal. Methodology A 5-year retrospective review of all patients with histopathological, immunohistochemical, and in situ hybridization proven cutaneous lymphomas Results We collected 7 cases corresponding to a frequency of 1.4 cases per year. ENKTCL accounted for 10.5% of all cutaneous lymphomas, ranking second after T-cell lymphomas. Men were predominantly affected (M : F ratio of 6) and the mean age was 38.5 years ± 4.06. The mean time before consultation was 7.3 months. The lymphomas affected primarily the nasal cavity in five cases and the skin in two cases. At admission, six patients had nasal mucosa involvement, which was isolated in three cases, associated with cutaneous lesions in three cases and lymph node involvement in three cases. CD56 was positive in only one case and Eber transcribed RNA of EBV was expressed by in situ hybridization in all patients. Discussion To our knowledge, we have reported the first and largest series of ENKTCLin Sub-Saharan Africa. Our study shows an intermediate prevalence between that reported from Asia, Latin America, and the West. It was also noted a young age of patients, a prolonged diagnostic delay, a frequent negativity of CD56 marker, and a very poor prognosis of the disease in our region. Introduction Extranodal NK/T-cell lymphoma (ENKTCL) is a rare entity, recently individualized in the new WHO classification and accounting for only 0.5% of Non-Hodgkin’s Lymphoma (NHL).1 It is characterized by its constant association with chronic EBV infection.2 The frequency of cutaneous involvement, as well as the poor prognosis of this lymphoma justifies its importance and relevance to the dermatologist.3 The distribution of ENKTCL is very inhomogeneous throughout the world.4 Thus, this lymphoma is more frequent in Asian countries, in addition to Central and South America, where it represents 5–10% of the NHL.5,6 In the West, it is exceptional, with an incidence of less than 1% of all lymphomas.7 In Sub- Saharan Africa (SSA), ENKTCL has been exceptionally reported despite the precocity and the endemicity of EBV infection.8,9 The purpose of


Auteur(s) : Diallo M, Diop A, Diatta BA , Ndiaye M, Ortonne N, Dieng MT.
Pages : 5
Année de publication : 2018
Revue : International journal Dermatology
N° de volume : 1
Type : Article
Mise en ligne par : DIATTA Boubacar Ahy